CURRICULUM VITAE

 

NAME:                                                    TASUKU HONJO

 

PLACE AND DATE OF BIRTH:           Kyoto, Japan

                                                                 January 27, 1942

 

PRESENT STATUS:                               Professor

                                                                 Department of Immunology and Genomic Medicine

                                                                 Kyoto University Graduate School of Medicine

                                                                 Kyoto, Japan

 

                                                                 Director

                                                                 Japan Society for the Promotion of Science

                                                                 Research Center for Science Systems

                                                                 6 Ichibancho, Chiyoda-ku, Tokyo 102-8471

                                                                       

TRAINING AND PREVIOUS POSITIONS:

 

                        1960-1962                          Premedical Course

                                                                 Kyoto University Faculty of Medicine

                                                                 Kyoto, Japan

 

                        1962-1966                          Medical Course

                                                                 Kyoto University Faculty of Medicine

                                                                 Kyoto, Japan

 

                        1966                                  M.D. (Kyoto University)

 

                        1966-1967                          Internship, Kyoto University Hospital

                                                                 Kyoto, Japan

 

                        1967-1971                          Graduate School (Medical Chemistry)

                                                                 Kyoto University, Kyoto, Japan

 

                        1975                                  Ph.D. (Kyoto University)

 

                        1971-1973                          Fellow of Carnegie Institution of

                                                                 Washington

                                                                 Department of Embryology

                                                                 Baltimore, Maryland

                        1973-1974                           Visiting Fellow and Associate

                                                                  Laboratory of Molecular Genetics

                                                                  National Institute of Child Health and                      

                                                                  Human Development, NIH

                                                                  Bethesda, Maryland

 

                       1974-1979                            Assistant Professor

                                                                  Department of Physiological Chemistry and

                                                                  Nutrition

                                                                  Faculty of Medicine University of Tokyo

                                                                  Tokyo, Japan

 

                       1979-1984                            Professor

                                                                  Department of Genetics

                                                                  Osaka University School of Medicine

                                                                  Osaka, Japan

 

                       1984-2005                            Professor

                                                                  Department of Medical Chemistry

                                                                  Kyoto University Faculty of Medicine

                                                                  Kyoto, Japan

 

                       1988-1997                            Director

                                                                  Center for Molecular Biology and Genetics

                                                                  Kyoto University

                                                                  Kyoto, Japan

 

                       1989-1997                            Professor

                                                                  Department of Molecular Genetics

                                                                  Institute of Neurological Disease

                                                                  Hirosaki University School of Medicine

                                                                  Aomori, Japan

 

                       1996-2000                            Dean

                                                                  Kyoto University Faculty of Medicine

 

                       1999-2003                            Science Adviser

                                                                  Ministry of Education, Culture, Sports, Science and

                                                                  Technology (MEXT)

 

                        2002-2004                           Dean

                                                                  Kyoto University Faculty of Medicine

 

                        2004-2006                          Director

                                                                  Japan Society for the Promotion of Science

                                                                  Research Center for Science Systems

 

2005-present                        Professor

Department of Immunology and Genomic Medicine

Kyoto University Faculty of Medicine

Kyoto, Japan

 

                        2006-present                      Executive Member

                                                                 The Council for Science and Technology Policy Cabinet Office

                                                                

 

 

AWARDS and HONOR

 

              1981                          Noguchi Hideyo-Memorial Award for Medicine

              1981                          Asahi Prize

              1984                          Osaka Science Prize

              1984                          Kihara Prize of the Japanese Genetics Society

              1985                          Erwin von Baelz Prize

              1988                          Takeda Medical Prize

              1991-1996                  Fogarty Scholar-in-residence at NIH

1992                                                     Behring-Kitasato Prize

1994                          Uehara Prize

              1996                          The Imperial Prize and the Japan Academy Prize

              2000                          Award gPersons of Cultural Merith by Japanese Government

2001                          Foreign Associate of U.S. National Academy of Sciences

2003                          Member of Leopoldina

                                 (The German Academy of Natural Scientists)

 

EDITOR

 

        Annales de L'Institut Pasteur immunology (1986-1988)

        Annual Review of Immunology (2004-

        Bio Essays (1984-1989)

        Biomedical Research (1981-

        Cancer Research (1990-2000)

        Clinical and Developmental Immunology (formerly known as Developmental

        Immunology, 2003-

        Current Biology (1993-2003)

        Current Opinion in Cell Biology (1989-1994)

        Current Opinion in Immunology (1993-

        Current Topics in Microbiology and Immunology (2003-

        Developmental Immunology (1989-2003)

        European Journal of Immunology (2003-2005)

        Gene Therapy (1993-

        Genes, Chromosomes & Cancer (1989-1995)

        Genomics (1987-2003)

        Growth Factors (1988-

        Immunological Review (1986-1996)

        Immunology Letters (1987-1992)

        International Immunology (1988-1996; 2001-

        Journal of Biochemistry (1986-1988)

        Journal of Molecular and Cellular Immunology (1989-1990)

        Molecular and Cellular Biochemistry (1987-1993)

        Molecular Biology & Medicine (1983-1990)

        Nucleic Acid Research (1986-1988)

        Oxford Surveys on Eukaryotic Gene (1988-1989)

        Progress in Growth Factor Research (1989-

        Research Update Advisory Panel (2003-

        Scandinavian Journal of Immunology (1991-1998)

        Science (1996-2002)

        Technique: A Journal of Methods in Cell and Molecular Biology  (1992-

        Telegen Report (1983-1988)

        The Journal of Clinical Investigation (1992-1997)

        The Journal of Experimental Medicine (1992-

      Trends in Immunology (1999-

 

MEMBERSHIP

 

            Japanese Society for Immunology (President 1999-2000)

            Japanese Society for Molecular Biology

            Japanese Biochemical Society

            Human Genome Organization

            American Association of Immunologists (Honorary Member)

 

COMMITTEE

 

            Fellowship review committee member of

            International Human Frontier Science Program

            (1992-1995; Chairman 1993-1995)

 

            External Advisory Board of the Committee for

            Human Gene Therapy Working Group (1996-

           

            Advisory committee member of RCAI (2005-

           

            First vice chair of the AAAS Japan Advisory Committee (2005-

           

            Councilor of Takeda Science Foundation (2005-

        

        

Selected Publications

 

Studies on Immunoglobulin genes and antibody Class switching

 

1.          Organization of immunoglobulin heavy chain genes and allelic deletion model.  Honjo, T. and Kataoka, T.  Proc. Natl. Acad. Sci. USA 75 2140-2144 (1978) 

 

2.          Cloning and complete nucleotide sequence of mouse imunoglobulin g1 chain gene.  Honjo, T., Obata, M., Yamawaki-Kataoka, Y., Kataoka, T., Kawakami, T., Takahashi, N. and Mano, Y.  Cell 18 559-568 (1979) 

 

3.          Rearrangement of immunoglobulin g1-chain gene and mechanism for heavy-chain class switch.  Kataoka, T., Kawakami, T., Takahashi, N. and Honjo, T.  Proc. Natl. Acad. Sci. USA 77 919-923 (1980) 

 

4.          Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome.  Yaoita, Y. and Honjo, T.  Nature 286 850-853 (1980)

 

5.          Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes.  Kataoka, T., Miyata, T. and Honjo, T.  Cell 23 357-368 (1981)

 

6.          Switch region of the immunoglobulin Cg gene is composed of simple tandem repetitive sequences.  Nikaido, T., Nakai, S. and Honjo, T.  Nature 292 845-848 (1981)

 

7.          Ordering of mouse immunoglobulin heavy chain genes by molecular cloning.  Shimizu, A., Takahashi, N., Yamawaki-Kataoka, Y., Nishida, Y., Kataoka, T. and Honjo, T.  Nature 289 149-153 (1981)

 

8.          Organization of the constant-region gene family of the mouse immunoglobulin heavy chain.  Shimizu, A., Takahashi, N., Yaoita, Y. and Honjo, T.  Cell 28 499-506 (1982)

 

9.          Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.  Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Azuma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T.  Nature 319 640-646 (1986)

 

10.      Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II.  Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindquist, S., Takahashi, M., Matsuda, F., Yaoita, Y., Takatsu, K. and Honjo. T.  Nature 324 70-73 (1986)

 

11.      Circular DNA is excised by immunoglobulin class switch recombination.  Iwasato, T., Shimizu, A., Honjo, T. and Yamagishi, H.  Cell 62 143-149 (1990)

 

12.      Signal sequence trap: cloning strategy for secreted proteins and type I membrane proteins.  Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T. and Honjo, T.  Science 261 600-603 (1993)

 

13.      The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.  Matsuda, F., Ishii, K., Bourvagnet, P., Kuma, K., Hayashida, H., Miyata, T. and Honjo, T.  J. Exp. Med. 188 2151-2162 (1998)

 

14.      Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.  Kinoshita, K., Tashiro, J., Tomita, S., Lee, C-G. and Honjo, T.  Immunity 9 849-858 (1998)

 

15.      Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA editing deaminase family in germinal center B cells.  Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O. and Honjo, T.  J. Biol. Chem. 274 18470-18476 (1999)

 

16.      Class switch recombination and hypermutation require activation- induced cytidine deaminase (AID), a potential RNA editing enzyme.  Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T.  Cell 102 553-563 (2000)

 

17.      Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2).  Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., D.-Lagelouse, R., Gennery, A., Tezcan, I., Ersoy, F., Kayserili, H., Ugazio, A.G., Brousse, N., Muramatsu, M., Notarangelo, L.D., Kinoshita, K., Honjo, T., Fischer, A. and Durandy, A.  Cell 102 565-575 (2000)

 

18.      AID is required to initiate Nbs 1/–H2AX focus formation and mutations at sites of class switching.  Petersen, S., Casellas, R., Reina-S-M, B., Chen, H., Difilippantonio, M., Wilson, P., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D., Redon, C., Ried, T., Bonner, W., Honjo, T., Nussenzweig, M. and Nussenzweig, A.  Nature 414 660-665 (2001)

 

19.      In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.  Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. and Honjo, T.  Nature 413 639-643 (2001)

 

20.      Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination.  Chen, X., Kinoshita, K. and Honjo, T.  Proc. Natl. Acad. Sci. USA 98 13860-13865 (2001)

 

21.      The AID enzyme induces class switch recombination in fibroblasts.  Okazaki, I., Kinoshita, K., Muramatsu, M., Yoshikawa, K. and Honjo, T.  Nature 416 340-345 (2002)

 

22.      The AID enzyme induces hypermutation in an actively transcribed gene in fibroblasts.  Yoshikawa, K., Okazaki, I., Eto, T., Kinoshita, K., Muramatsu, M., Nagaoka, H. and Honjo, T.  Science 296 2033-2036 (2002)

 

23.      Constitutive expression of AID leads to tumorigenesis.  Okazaki, I., Hiai, H., Kakazu, N., Yamada, S., Muramatsu, M., Kinoshita, K. and Honjo, T.  J. Exp. Med. 197 1173-1181 (2003)

 

24.      AID mutant analyses indicate requirement for class-switch-specific cofactors.  Ta, V-T., Nagaoka, H., Catalan, N., Durandy, A., Fischer, A., Imai, K., Nonoyama, S., Tashiro, J., Ikegawa, M., Ito, S., Kinoshita, K., Muramatsu, M. and Honjo, T.  Nature Immunol. 4 843-848 (2003)

 

25.      Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.  Begum, N. A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L. A., Jaenisch, R. and Honjo, T.  Science 305 1160-1163 (2004)

 

Studies on Immuno-inhibotory receptor PD-1

1.          Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.  Ishida, Y., Agata, Y., Shibahara, K. and Honjo, T.  EMBO J. 11 3887-3895 (1992)

 

2.          Development of lupus-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T.  Immunity 11 141-151 (1999)

 

3.          Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.  Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitsz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T.  J. Exp. Med. 192 1027-1034 (2000)

 

4.          PD-L2, a novel B7 homologue, is a second ligand for PD-1 and inhibits T cell activation.  Latchman, Y., Wood, C., Chernova, T., Borde, M., Chernova, I., Iwai, Y., Malenkovich, N., Long, A., Bourque, K., Boussiotis, V., Nishimura, H., Honjo, T., Sharpe, A. and Freeman, G.  Nature Immunol. 2 261-268 (2001)

 

5.          Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice.  Nishimura, H., Tanaka, Y., Okazaki, T., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Hiai, H., Minato, N. and Honjo, T.  Science 291 319-322 (2001)

 

6.          Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.  Iwai, Y., shida, M., Tanaka, Y., Okazaki, T., Honjo, T. and Minato, N.  Proc. Natl. Acad. Sci. USA 99 12293-12297 (2002)

 

7.          Autoantibodies against cardiac troponin I are responsible for the dilated cardiomyopathy in PD-1 deficient mice.  Okazaki, T., Tanaka, Y., Nishio, R., Mitsuie, T., Mizoguchi, A., Jian, W., Ishida, M., Matsumori, A., Minato,. N. and Honjo, T.  Nature Medicine 9 1477-1483 (2003)

 

Studies on Cell differentiation by Notch target gene PBP-J

1.          A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.  Matsunami, N., Hamaguchi, Y., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi M. and Honjo, T.  Nature 342 934-937 (1989)

 

2.          The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.  Furukawa, T., Maruyama, S., Kawaichi, M. and Honjo, T.  Cell 69 1191-1197 (1992)

 

3.          Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophila Suppressor of Hairless.  Zimber-Strobl, U., Strol, L. J., Meitinger, C., Hinrichs, R.,Sakai, T., Furukawa, T., Honjo, T. and Bornkamm. G. W.  EMBO. J. 13 4973-4982 (1994)

 

4.          Physical interaction between a novel domain of the receptor notch and the transcription factor RBP-Jk/Su(H).  Tamura, K., Taniguchi, Y., Minoguchi, S., Sakai, T., Tin Tun, Furukawa, T. and Honjo, T.  Curr. Biol. 5 1416-1423 (1995)

 

5.          Disruption of the mouse RBP-Jk gene results in early embryonic death.  Oka, C., Nakano, T., Wakeham, A., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T. and Honjo, T. Development 121 3291-3301 (1995)

 

6.          Involvement of RBP-J in biological functions of mouse Notch 1 and its derivatives.  Kato, H., Taniguchi, Y., Kurooka, H., Minoguchi, S., Sakai, T., Nomura-Okazaki, S., Tamura, K. and Honjo, T.  Development 124 4133-4141 (1997)

 

7.        Notch-signalling controls pancreatic cell differentiation.  Apelqviist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Hrabe, M. H., Lendahl, U. and Edlund, H.  Nature 400 877-881 (1999)

 

8.          Notch / RBP-J signaling is involved in cell fate determination of marginal zone B cells.  Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K. and Honjo, T.  Nature Immunol. 3 443-450 (2002)

 

9.          Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.  Kuroda, K., Han, H., Tani, S., Tanigaki, K., Tin Tun, Furukawa, T., Taniguchi, Y., Kurooka, H., Hamada, Y., Toyokuni, S. and Honjo, T.  Immunity 18 1-20 (2003)

 

10.      Regulation of ab gd T cell lineage commitment and peripheral T cell response by Notch/RBP-J signaling. Tanigaki, K., Tsuji, M., Yamamoto, N., Han, H., Tsukada, J., Inoue, H., Kubo, M and Honjo, T.  Immunity 20 611-622 (2004)

 

11.      Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells. Amsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T. and Flavell, R. A.  Cell 117 515-526 (2004)

 

Studies on Isolation of IL-2 receptor alpha chain

1.          Molecular cloning of cDNA encoding human interleukin-2 receptor.  Nikaido, T., Shimizu, A., Ishida, N., Sabe, H., Teshigawara, K., Maeda, M., Uchiyama, T., Yodoi, J. and Honjo, T.  Nature 311 631-635 (1984)

 

2.          Expression of functional human interleukin 2 receptor in mouse T cells by cDNA transfection.  Kondo, S., Shimizu, A., Maeda, M., Tagaya, Y., Yodoi, J. and Honjo, T.  Nature 320 75-77 (1986)

 

3.          Expression and functional characterization of artificial mutants of interleukin-2 receptor.  Kondo, S., Kinoshita, M., Shimizu, A., Saito, Y., Konishi, M., Sabe, H. and Honjo, T.  Nature 327 64-67 (1987)

 

4.          Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice.  Nishi, M., Ishida, Y. and Honjo, T.  Nature 331 267-269 (1988)

 

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