Members

Shigekazu NAGATA

Professor

Shigekazu NAGATA

Curriculum Vitae

1968-72 Undergraduate Student Faculty of Science, University of Tokyo

1972-77 Graduate Student Department of Chemistry, Institute of
Medical Science, University of Tokyo


1977-77 Research Associate Department of Chemistry, Institute of Medical Science, University of Tokyo

1977-81
 Post-Doctral Fellow Institute of Molecular Biology, University of Zurich

1982-87
 Assistant Professor at the Institute of Medical Science,
University of Tokyo

1987-98
 Head, Department of Molecular Biology, Osaka Bioscience Institute

1995-07
  Professor, Department of Genetics, Graduate School of Medicine, Osaka University

2002-07
  Professor, Integrated Biology Laboratories, Graduate School of Frontier Bioscience, Osaka University

2007-
  Professor, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University

Awards

1986 The Encouragement Award (Japan Biochemical Society)
1990 Erwin von Balz Preis (Tokyo)
1992 The Mochida Memorial Award (Tokyo)
1993 Nikkei BP Prize (Tokyo)
1994 Emil von Boehring Preis (Marburg Univ., Germany)
1995 Robert Koch Preis (Bonn, Germany)
1995 Osaka Science Prize (Osaka)
1996 Boehring-Kitasato Prize (Tokyo)
1997 Prix Lacassagne (Paris, France)
1997 Mellon Prize (Univ. of Pittsburgh, USA)
1998 Asahi Prize (Tokyo)
1998 Takmatsu Cancer Award (Tokyo)
1998 Uehara Prize (Tokyo)
2000 Japan Academy Prize, Imperial Prize (Japan)
2001 Person of Cultural Merits (Japan)
2012 Honorary Doctorate (Univ. of Zurich, Switzerland)

2012 Debrecen Award (Debrecen University/ Hungary)

2013 Keio Medical Science Prize (Keio Univ./Japan)

■Editorial board

1994- Cell Death and Diff.
1995- Genes to Cell
1996- Apoptosis
1997- Int. Immunol.
1998- Immunity
1998- Exp. Cell Res.
1999- Biochem. Biophys. Acta
1999- IUBMB/Life
2000- Science
2000- Int. J. Cancer
2002- Cancer Cell

Jun Suzuki

Assistant professor

Jun SUZUKI

■Name

Jun SUZUKI
e-mail:jsuzuki [at] mfour.med.kyoto-u.ac.jp

■Education
2007 Ph.D., Osaka University, Japan
■Research Experiences
2007-2010 Research Fellow, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
2010-present Assistant Professor, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
■Awards
2006 IUBMB Young Scientist Award
2011/05 2010 Young Scientist Best Paper Award from Kyoto University,Graduate School of Medicine
2014/04 The Young Scientists’ Prize (from the Minister of Education, Culture, Sports, Science and Technology)
2014/10 The Japanese Biochemical Society encouragement prize.
■Selected Publications

Suzuki J., Denning DP., Imanishi E., Horvitz HR. and Nagata, S. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
Science, 341: 403-406 (2013)

Segawa K., Suzuki J. and Nagata S. Constitutive exposure of phosphatidylserine on viable cells
Proc. Natl. Acad. Sci. U. S. A., 108, 19246-19251 (2011)

Suzuki J., Umeda M., Sims P.J. and Nagata S. Calcium-dependent phospholipid scrambling by TMEM16F.
Nature. 468, 834-838 (2010)

Hirano N, Sato S, Gotoh T, Maruoka M, Suzuki J, Matsuda S, Shishido T and Tani K.NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
FEBS Lett. 580, 6464-6470 (2006)

Kawata S, Suzuki J, Maruoka M, Mizutamari M, Ishida-Kitagawa N, Yogo K, Jat PS and Shishido T.  Retrovirus-mediated conditional immortalization and analysis of established cell lines of osteoclast precursor cells.
Biochem. Biophys. Res. Commun. 350, 97-104 (2006)

Suzuki J*, Fukuda M*, Kawata S, Maruoka M, Takeya T, and Shishido T. *equal contribution.  A rapid protein expression and purification system using Chinese hamster ovary cells expressing retrovirus receptor.
J. Biotechnol. 126, 463-474 (2006)

Maruoka M*, Suzuki J*, Kawata S, Yoshida K, Hirano N, Sato S, Goff SP, Takeya T, Tani K and Shishido T. *equal contribution  Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinase.
FEBS Letters 579, 2986-2990 (2005)

Suzuki J, Sukezane T, Akagi T, Georgescu MM, Ohtani M, Inoue J, Jat PS, Goff SP, Hanafusa H, and Shishido T.  Loss of c-abl facilitates anchorage-independent growth of p53- and RB- deficient primary mouse embryonic fibroblasts.
Oncogene 23, 8527-8534 (2004)

■Review

Hanayama R, Miyanishi M, Yamaguchi H, Suzuki J and Nagata S.
Engulfment of apoptotic cells and its physiological roles.
Cell Death, G. Melino and D.Vaux, eds. (John Wiley & Sons) 165-175 (2009).

Suzuki J and Shishido T.
Regulation of anchorage-independent growth by Abl kinases.
J. Biochem. 141, 453-458 (2007)

Suzuki J, Maruoka M, Kawata S and Shishido T.
A rapid protein expression and purification system using Chinese hamster ovary cells using flow cytometry.
Cytometry Res. 17, 35-42 (2007)

Shishido T, Suzuki J and Tani K.
Mechanism of c-Abl kinase activation by adaptor proteins.
Seikagaku 78, 521-525 (2006)

Shishido T and Suzuki J.
Regulation of Abl kinase by adaptor proteins.
Gene Ther. Mol. Biol. 9, 339-342 (2005)

Hiroshi YAMAGUCHI

Assistant professor

Hiroshi YAMAGUCHI

PhD

■Name

Hiroshi YAMAGUCHI
e-mail:hyamaguchi [at] mfour.med.kyoto-u.ac.jp

■Education
2009 Ph.D., Osaka University, Japan
■Research Experiences
2009-2011 Research Fellow, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
2011-present Assistant Professor, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
■Awards
Best presentation award
(The 17th Annual Meeting of the Japanese Society for Apoptosis)
■Publications

Yamaguchi, H., Maruyama, T., Urade, Y. and Nagata, S.Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.
eLife., 3: e02172 (2014)

Yamaguchi, H., Takagi, J., Miyamae, T., Yokota, S., Fujimoto, T., Nakamura, S., Ohshima, S., Naka, T., and Nagata, S. Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus.
J.Leukoc.Biol.(2008) 83: 1300-1307. (cover)

Yamaguchi, H., Fujimoto, T., Nakamura, S., Ohmura, K., Mimori, T., Matsuda, F., and Nagata, S. Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus.
Eur J Immunol. (2010) 40: 1778-1785

■Review

Hanayama, R., Miyanishi, M., Yamaguchi, H., Suzuki, J., Nagata, S.Engulfment of apoptotic cells and its physiological roles (Review).
Encyclopedia of Life Science (Cell Death). (2010) 165-175

Yamaguchi, H., Nagata, S. Engulfment of apoptotic cells in our bodies.
Jikken Igaku (Experimental Medicine). (2010) 1048-1054

Katsumori Segawa

Assistant professor

Katsumori Segawa

PhD

■Name

Katsumori Segawa
e-mail:k-segawa [at] mfour.med.kyoto-u.ac.jp

■Education
2009 Ph.D., Osaka University, Japan
■Research Experiences
2006-2009 JSPS research fellow (DC1)
2009-2011 Research Fellow, Department of Medical Chemistry,Kyoto University,Graduate School of Medicine
Apr/2011-Oct/2011 JSPS research fellow (PD)
Nov/2011-present Assistant Professor, Department of Medical Chemistry,Kyoto University,Graduate School of Medicine
■Selected Publications

Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, TR., Matsuda, F. and Nagata, S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
Science, 344: 1164-1168 (2014)

Katsumori Segawa, Jun Suzuki, and Shigekazu Nagata Constitutive exposure of phosphatidylserine on viable cells
Proc. Natl. Acad. Sci. U. S. A., 108, 19246-19251 (2011)

Katsumori Segawa, Morihiro Matsuda, Atsunori Fukuhara, Kentaro Morita, Yosuke Okuno, Ryutaro Komuro, and Iichiro Shimomura Identification of a novel distal enhancer in human adiponectin gene.
The Journal of Endocrinology., 200(1), pp. 107-116, 2009

Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka,Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, and Iichiro Shimomura Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation.
Diabetes., 56(4), pp.901-11, 2007

Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Yosuke Okuno, Manabu Abe, Naomi Hosogai, Morihiro Matsuda, Ryutaro Komuro, and Iichiro Shimomura Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes.
Biochem Biophys Res Commun., 364(1), pp.33-39, 2007

Katsumori Segawa, Atsunori Fukuhara, Naomi Hosogai, Kentaro Morita, Yosuke Okuno, Masaki Tanaka, Yasuhiko Nakagawa, Shinji Kihara, Tohru Funahashi, Ryutaro Komuro, Morihiro Matsuda, and Iichiro Shimomura Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism.
Biochem Biophys Res Commun., 7;349(3), pp.875-82, 2006


Toshihiro Fujii

Assistant Professor

Fujii Toshihiro

■Name

Toshihiro Fujii
e-mail: tfujii [at] mfour.med.kyoto-u.ac.jp

■Education
2010 Ph.D., Osaka University, Japan
■Research Experienced
2010-2012 Research Fellow, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
2011-present Assistant Professor, Department of Medical Chemistry,Kyoto University Graduate School of Medicine, Japan
■publication

Fujii T, Ueda T, Nagata S, Fukunaga R
Essential Role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression.
THE JOURNAL OF BIOLOGICAL CHEMISTRY vol.285, No.39, pp.30214-30223 (2010)

  • Secretary
  • Makiko FUJII
  • Technical Staff
  • Eiichi IMANISHI
  • Technical Staff
  • Ryusei KOSUGI
  • Technical Staff
  • Sachiko KKURATA
  • Guest Investigator
  • Takashi FUJIMOTO
  • Postdoctoral Fellow
  • Yuichi YANAGIHASHI
  • Postdoctoral Fellow
  • Yoko MORIOKA
  • Postdoctoral Fellow
  • Satoshi TODA
  • DC4
  • Kenji ISHIHARA
  • DC3
  • Sayuri GYOBU
  • DC2
  • Chihiro NISHI
  • MC2
  • Shoko YOSHIKAWA
members

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